The main focus of the third Up Close and Personalized Congress is to examine the essential clinical, genomic, proteomic, metabolomic, pharmacogenomic, biomarker data and imaging necessary to predict, prevent and treat major medical conditions concerning metabolism (diabetes and obesity), cardiovascular and cancer. We will be to explore bio-informatic tools, algorithms, artificial intelligence techniques, decision support systems and other new platforms for disease prediction and better tailoring treatment modeling to the individual patient. Furthermore, we will discuss policy issues such as barriers for implementing Personalized Medicine, health and quality assurance.