[Information systems] is not limited to use of Computers while Computing. The primal components of [Information Systems] includes [Hardware, Software and [Man-kind] as the only Producer and User of [Data – Knowledge – Information]. All species within the physical reality have capability for desire, thus are engaged in computing and developing ecosystemic remedial measures of the ongoing conundrums, Challenges and disorders; as indicated by the increasing global efforts to control the Global challenges. The knowledge of [Information Systems] by which a species depends on to resolve the known physical conundrums influences the worth of [Physical Outcomes] manifesting into physical reality. The [Man-kind] of species is resolving [OUTCOMES] but not [CAUSES] of the increasing [Conundrums of physicality]. The cause of the physical reality is the capability for desire; but now increasingly growing in Malevolescence and Virulence. Knowledge of reality is limited to knowledge of the [OUTCOMES] or the physical perspectives of reality (Arts and Sciences).