The International Conference on eXtended Reality (XR Salento) is an event dedicated to the eXtended Reality (XR). To cope with the increasing demand of application of XR technologies in several fields, XR Salento 2023 will be an event also dedicated to Digital Twins embracing Internet of Things, Artificial Intelligence, and Data Mining in order to create a digital representation, gather and store real-time data, simulate the future state, and provide a basis for optimization.